Behaviour of Tetrabenazine in Acid Medium: Reassessment and Impact on Formulation
Thorough studies of previous analytical stress data of tetrabenazine, a dopamine depleting agent, showed a potential susceptibility to acidic conditions.Hence, the behavior of tetrabenazine acidic solutions was studied by LC-MS and NMR spectroscopy.Reverse-phase LC-MS analysis of tetrabenazine acidic aqueous solutions consistently showed a main lip